NFL Week 13 Picks & Predictions: Scores, Upsets, and Expert Breakdowns

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NFL.com editors Ali Bhanpuri, Tom Blair, Brooke Cersosimo, Gennaro Filice, and Dan Parr are back with their Week 13 predictions — complete with score picks, matchup breakdowns, upset alerts, and plenty of drama for a packed Thanksgiving week slate.


Analyst Records (Straight-Up & ATS)

AnalystStraightATSO/USolo YOLO (SU)Solo YOLO (ATS)
Ali121-5686-9090-887-46-4
Brooke116-6179-9792-866-915-16
Dan123-5484-9292-860-12-1
Gennaro116-6189-8789-893-119-8
Tom121-5684-9281-973-36-4

THURSDAY, NOV. 27


Packers (7-3-1) at Lions (7-4)

Ford Field | 1:00 PM ET (FOX)
Line: Lions -2.5 | O/U: 48.5

All analysts pick Detroit

Predicted scores:
Lions win by 2–6 points across the board.

Why Lions?
Detroit got bullied by Green Bay in Week 1, but Gennaro expects that to flip at home. Packers’ offense is flat, Jahmyr Gibbs is hot, and Ford Field’s turf should boost Detroit’s speed. Expect a tight divisional rematch with the Lions edging it out.


Chiefs (6-5) at Cowboys (5-5-1)

AT&T Stadium | 4:30 PM ET (CBS)
Line: Chiefs -3.5 | O/U: 52.5

Picks:
Cowboys: Brooke
Chiefs: Ali, Dan, Gennaro, Tom

Why Cowboys?
Dallas’ defense has transformed since adding DT Quinnen Williams. Dak Prescott is red-hot, and Mahomes’ recent slump (1 TD, 3 INT since Week 9) opens the door. Brooke bets on Dallas’ Thanksgiving-day energy at home.


Bengals (3-8) at Ravens (6-5)

M&T Bank Stadium | 8:20 PM ET (NBC)
Line: Ravens -7 | O/U: 51.5

All analysts pick Baltimore

Why Ravens?
Joe Burrow returns, but the Bengals still field the league’s worst defense and a shaky O-line. Lamar hasn’t been perfect, but Baltimore’s pass rush (top 5 recently) should be the difference.


FRIDAY, NOV. 28


Bears (8-3) at Eagles (8-3)

Lincoln Financial Field | 3:00 PM ET (Prime Video)
Line: Eagles -7

Picks:
Bears: Ali
Eagles: Brooke, Dan, Gennaro, Tom

Why Eagles?
Tom is nervous picking Philly, but trusts their defense (No. 6 in EPA/play) to step up against a gritty Bears team. Chicago has been much better since Week 5, but the Eagles’ defense gets the nod at home.


SUNDAY, NOV. 30


Rams (9-2) at Panthers (6-6)

Line: Rams -10

All analysts pick Rams

Why Rams?
L.A. is the hottest team in football — dominant defense, efficient offense, and zero hesitation on 4th downs thanks to their field-goal allergy. Ali sees an easy road win.


49ers (8-4) at Browns (3-8)

Line: 49ers -4.5

All analysts pick 49ers

Why 49ers?
Shedeur Sanders faces a scarier defense than last week. Myles Garrett is a one-man wrecking crew for Cleveland, but San Francisco’s balance and Christian McCaffrey’s workload give them the edge.


Texans (6-5) at Colts (8-3)

Line: Colts -4.5

Picks:
Texans: Dan, Tom
Colts: Ali, Brooke, Gennaro

Why Texans (Dan’s upset pick)?
Texans’ defense is elite. They allow fewer passing TDs than interceptions — the only team in the NFL with that stat. If Houston avoids turnovers, they can shock the AFC’s No. 1 scoring offense.


Saints (2-9) at Dolphins (4-7)

Line: Dolphins -5.5

All analysts pick Miami

Why Dolphins?
Miami has quietly transformed from 1–6 bottom-feeders to a respectable, balanced team. New Orleans’ offense under rookie Tyler Shough is averaging just 10 PPG. Tom calls this a “we’re not as bad as you think” Miami win.


Falcons (4-7) at Jets (2-9)

Line: Falcons -2.5

Picks:
Jets: Gennaro
Falcons: Ali, Brooke, Dan, Tom

Why Jets (Gennaro’s upset pick)?
Jets have only one takeaway all year — an NFL record. He predicts that changes against a fading Kirk Cousins. Jets steal a scrappy home win.


Cardinals (3-8) at Buccaneers (6-5)

Line: Buccaneers -2.5

Picks:
Cardinals: Ali
Buccaneers: Brooke, Dan, Gennaro, Tom

Why Cardinals?
Tampa has dropped three straight and now Baker Mayfield’s shoulder is banged up. Arizona keeps losing close games but looks more stable than the injury-riddled Bucs right now.


Jaguars (7-4) at Titans (1-10)

Line: Jaguars -6.5

Picks:
Titans: Gennaro
Jaguars: Ali, Brooke, Dan, Tom

Why Jaguars?
Dan sees upset potential but sticks with Jacksonville. Trevor Lawrence is turnover-prone lately, but Tennessee’s offense struggles too much to trust.


Vikings (4-7) at Seahawks (8-3)

Line: Seahawks -11.5

All analysts pick Seattle

Why Seahawks?
Minnesota is collapsing, J.J. McCarthy is in concussion protocol, and undrafted rookie Max Brosmer is likely starting. Seattle has a ferocious defense and Sam Darnold is playing the best football of his career.


Raiders (2-9) at Chargers (7-4)

Line: Chargers -10

All analysts pick Chargers

Why Chargers?
Las Vegas is struggling to stay competitive and the Chargers have too much offensive firepower. Tom doesn’t overthink it — L.A. rolls.

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